Validated Stability-Indicating HPLC Method for the Determination of Mesna in Presence of Its Degradation Products

Validated stability-indicating HPLC method for the determination of mesna in presence of its degradation products.

A rapid and simple stability-indicating liquid chromatographic method was developed and validated for analysis of mesna in the presence of its degradation products in drug substance and drug products in a run time not >5 min. The separation was achieved on a RP amide C16 column at room temperature using methanol-phosphate buffer (10:90, v/v, pH 3.0) as mobile phase at a flow rate of 1 mL min(-1...

validated stability indicating hplc method for the determination of mebeverine in the presence of its degradation products: kinetics study of its degradation in oxidative condition

Validated stability indicating methods for determination of nitazoxanide in presence of its degradation products*

Three sensitive, selective and reproducible stability-indicating methods are presented for determination of nitazoxanide (NTZ), a new anti-protozoal drug, in presence of its degradation products. Method A utilizes the first derivative of ratio spectra spectrophotometry by measurement of the amplitude at 364.4 nm using one of the degradation products as a divisor. Method B is a chemometric-assis...

a stability indicating hplc method for determination of mebeverine in the presence of its degradation products and kinetic study of its degradation in oxidative condition

an hplc method for determination of mebeverine hydrochloride (mh) in the presence of its degradation products was developed. the degradation of mh was studied under hydrolysis, oxidative and photolysis stress conditions. under alkaline, acidic and oxidative conditions, degradation of mh was observed. the separation was performed using a symmetry c 18 column and a mixture of 50 mm kh 2 po 4 , ac...

A stability indicating HPLC method for determination of mebeverine in the presence of its degradation products and kinetic study of its degradation in oxidative condition

An HPLC method for determination of mebeverine hydrochloride (MH) in the presence of its degradation products was developed. The degradation of MH was studied under hydrolysis, oxidative and photolysis stress conditions. Under alkaline, acidic and oxidative conditions, degradation of MH was observed. The separation was performed using a Symmetry C18 column and a mixture of 50 mM KH2PO4, acetoni...